Man! How could I get this far and not mention Mozy?
Mozy's an online backup service that I profiled for InformationWeek earlier in the year. I dubbed it the pick of the pack, not just because it works well and has a generous storage policy (2GB for free, and only $5 a month for essentially unlimited storage), but because it's invisible. You install it, you point out what you want to back up, it runs silently in the background at designated times, and that's it.
I still use Vista's own backup tool to make local offline backups of a lot of stuff, but I use Mozy for the most crucial things: email, documents, etc. And so far it's saved my bacon at least once.
[Full disclosure: The link I listed above is an affiliate link. If you sign up with it, I get a little more storage added to my own account. Everyone who signs up can create such a link to spread the love a little.]

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